Название: Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer Автор: Waters M., Hughes C. Издательство: Wiley Год: 2018 ISBN: 978-1-119-02360-9 Формат: PDF Страниц: 774 Размер: 13.7 Mb Язык: English
Translational biomedical research seeks to move laboratory findings based on models (in silico, in vitro, and in vivo) into human clinical trials to more expeditiously develop specific therapeutics, and then back again to the laboratory to inform future discovery [1]. From the background of developmental toxicology, it is well known that toxicant exposures may affect critical events in reproductive development, ranging from early primordial germ cell determination to gonadal differentiation, gametogenesis, external genitalia, or signaling events regulating sexual behavior. Translational genetic toxicology takes advantage of this developmental perspective to assess potential germ line mutagenesis or to study the potential for cancer in the fetus or offspring or the adult as the result of environmental exposures. Translational toxicology must strive to identify applicable therapeutics that can safely and effectively identify and help to mitigate potential harm from natural as well as anthropogenic environmental exposures.
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Translational Toxicology and Therapeutics 
