Contributors vii
Preface xi

1. Introduction to Cancer Biology 1
Lea Harrington, Robert G. Bristow, Richard P. Hill, and Ian F. Tannock

2. Methods of Molecular Analysis 5
Anthony M. Joshua, Paul C. Boutros, and Th omas Kislinger

3. Cancer Epidemiology 51
Gord Fehringer, Rayjean J. Hung, and Geoff rey Liu

4. Chemical Carcinogenesis 73
Denis M. Grant

5. Genomic Stability and DNA Repair 89
Shane M. Harding, Robert G. Bristow, and Lea Harrington

6. Oncogenic Viruses and Tumor Viruses 117
Fei-Fei Liu and Christopher D. Richardson

7. Oncogenes and Tumor-Suppressor Genes 147
Previn Dutt and Vuk Stambolic

8. Cellular Signaling Pathways 173
Michael Reedijk and C. Jane McGlade

9. Cell Proliferation and Death 193
Paul Jorgensen and Razqallah Hakem

10. Tumor Progression and Metastasis 219
Yang W. Shao, Rama Khokha, and Richard P. Hill

11. Angiogenesis 243
Janusz Rak

12. Tumor Growth, Microenvironment, and Metabolism 271
Rob A. Cairns, Ian F. Tannock, and Bradly Wouters

13. Heterogeneity in Cancer: The “Cancer Stem Cell” Hypothesis 295
Craig Gedye

14. Imaging in Oncology 317
David A. Jaff ray

15. Molecular and Cellular Basis of Radiotherapy 333
Shane M. Harding, Richard P. Hill, and Robert G. Bristow

16. Tumor and Normal Tissue Response to Radiotherapy 357
Richard P. Hill and Robert G. Bristow

17. Discovery and Evaluation of Anticancer Drugs 393
Aaron D. Schimmer and Ian F. Tannock

18. Pharmacology of Anticancer Drugs 419
Eric X. Chen

19. Drug Resistance 443
Susan P.C. Cole and Ian F. Tannock

20. Hormones and Cancer 469
Paul S. Rennie, Eric Leblanc, and Leigh C. Murphy

21. The Immune System and Immunotherapy 501
Linh T. Nguyen, Evan F. Lind, and Pamela S. Ohashi

22. Guide to Clinical Studies 529
Eitan Amir and Ian F. Tannock

Index 553